Custom Peptides
Cayman Chemical RGDtargetd ProapoptoTCpep 10mg
A peptide; contains an integrin-binding cyclic region (CDCRGDCFC) and a region similar to a pro-apoptotic heptadimer sequence (klaklakklaklak), both of which are found in similar peptides
Cayman Chemical SPAA-52amonIum salt 10mg
An LMW-PTP inhibitor (Ki = 1.2 nM); greater than 8,000-fold selective for LMW-PTP over 24 phosphatases at 10 µM
Cayman Chemical SB-224289hydrochlorIde 10mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors
Cayman Chemical Vaborbactam 10mg
A β-lactamase inhibitor (Kis = 29-110 nM for class A and class C enzymes); selective for bacterial β-lactamases over a panel of mammalian serine proteases (IC50s = ≥1,000 μM); potentiates the activity of biapenem against K. pneumonia expressing KPC-2 at 0.02 μg/ml; potentiates the activity of carbapenem antibiotics against clinical isolates of various bacteria (MICs = ≤0.06-4 and 4-64 μg/ml in the presence and absence of compound, respectively); reduces the number of CFUs in the lung in a neutropenic mouse lung infection model when used in combination with biapenem or meropenem at 50 mg/kg
Cayman Chemical NpTosylGlyProLyspNAac 10mg
A colorimetric plasmin substrate; hydrolysis releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of plasmin activity
Cayman Chemical DIhydrocurcumIn 10mg
An active metabolite of curcumin; reduces triglyceride levels and increases glucose uptake in HepG2 and L-02 cellular models of oleic acid-induced steatosis at 20 µM
Cayman Chemical RnaconItIn 10mg
An alkaloid with analgesic and anesthetic activities (ED50s = 6.99 and 0.167 µmol/kg, respectively, in mice)
Cayman Chemical 3-FormylsalIcylIc AcId 10mg
An inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM); has been used in the synthesis of Schiff bases
Cayman Chemical RopInIrolehydrochlorIde 10mg
A dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay); selective for D2 over D1 dopamine receptors (Ki = >100,000 nM), as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM); reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg; induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice; reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of MPTP-induced Parkinson's disease
Cayman Chemical Dynole 34-2 10mg
A dynamin inhibitor (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively); induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells at 10 µM; inhibits proliferation of several cancer cell lines (GI50s = 5.8-15 µM)
Cayman Chemical MapenterolhydrochlorIde 10mg
A β2-AR agonist; has been used as a standard for the simultaneous detection of multiple drug residues in commercial livestock synovial fluids by GC-MS; has been used as an illicit feed additive to promote growth in livestock
Cayman Chemical TImosaponIn BII 10mg
A steroidal saponin with diverse biological activities; inhibits superoxide generation in isolated human neutrophils from 20-100 µM; reduces EV71-induced cell death in Vero cells (IC50 = 4.3 µM); inhibits ADP-induced platelet aggregation in isolated rabbit PRP at 20, 40, and 80 mg/ml; increases APTT and decreases the wet weight and length of thrombi in Chandler’s ex vivo thrombosis model at 3 and 6 mg/kg
Cayman Chemical 7hydroxy DPAThydrobromIde 10mg
A dopamine D3 receptor agonist; selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays); increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 = 13.5 nM in a FLIPR assay); decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg, i.p.; reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinson's disease at 2 UG/µl for eight weeks, i.c.v.; decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model
Cayman Chemical nrIdronIc AcId 10mg
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
Cayman Chemical SulforhodamIn BsodIM salt 10mg
An aminoxanthene dye; binds basic amino acid residues under mild acidic conditions, which can be quantified by colorimetric detection at 510 nM